Cialis (tadalafil) undergoes significant hepatic metabolism. The primary enzyme responsible is CYP3A4, a cytochrome P450 enzyme located in the liver. This enzyme breaks down tadalafil, reducing its concentration in the bloodstream.
CYP3A4 Inhibitors and Inducers
Drugs that inhibit CYP3A4 increase Cialis levels, potentially leading to heightened effects or side effects. Conversely, drugs that induce CYP3A4 decrease Cialis levels, potentially reducing its effectiveness. Always inform your doctor of all medications you’re taking, including over-the-counter drugs and supplements, to avoid harmful interactions.
Other Metabolic Pathways
While CYP3A4 is the dominant pathway, other minor pathways also contribute to Cialis metabolism. These pathways involve various enzymes and contribute to the overall elimination of the drug from the body. The relative contribution of these minor pathways is generally less significant than CYP3A4.
Consult your physician for personalized advice concerning Cialis and liver function. They can assess your individual situation and provide tailored recommendations based on your health status and other medications you are taking.
