Avoid concurrent use with MAO inhibitors. A minimum two-week interval between stopping an MAO inhibitor and starting cyproheptadine is recommended, and vice versa.
Cyproheptadine can potentiate the sedative effects of alcohol, opioids, and other central nervous system depressants. Use caution when combining it with these medications, and reduce dosage where appropriate.
Be aware of increased risk of drowsiness and impaired cognitive function when taking cyproheptadine with other sedating medications, including antihistamines and some antidepressants.
Cyproheptadine may interact with medications metabolized by the liver’s cytochrome P450 system, potentially altering their effectiveness. Discuss this with your doctor or pharmacist if you take other medications.
Individuals with glaucoma, prostatic hyperplasia, or pyloroduodenal obstruction should exercise caution and consult their doctor before using cyproheptadine, as it may worsen these conditions.
Pregnant or breastfeeding women should only use cyproheptadine under strict medical supervision due to potential risks to the fetus or infant.
Patients with a history of seizures should use cyproheptadine cautiously; it may lower the seizure threshold.
Elderly patients may be more susceptible to the side effects of cyproheptadine, especially drowsiness. A lower dose might be recommended.
Always inform your doctor or pharmacist of all medications you are taking, including over-the-counter drugs and herbal supplements, to prevent potentially harmful interactions.
