Advair Diskus contains salmeterol and fluticasone propionate. These interact with several medications. Always inform your doctor or pharmacist about all medications, including over-the-counter drugs, herbal remedies, and supplements you are taking.
Specifically, Advair can interact with ketoconazole, itraconazole, erythromycin, and other strong CYP3A4 inhibitors. These drugs can increase fluticasone levels, potentially leading to increased side effects. Your doctor may need to adjust your Advair dose or choose an alternative treatment.
Beta-blockers, such as metoprolol or atenolol, can counteract the bronchodilating effects of salmeterol. Using both medications together may lessen the effectiveness of Advair in managing your breathing problems. Discuss this with your doctor before combining them.
Grapefruit juice inhibits the metabolism of certain drugs. While not specifically studied with Advair, it’s prudent to avoid grapefruit juice while using this medication, as it could potentially elevate drug levels.
| CYP3A4 Inhibitors | Ketoconazole, Itraconazole, Erythromycin | Increased fluticasone levels, potential for increased side effects |
| Beta-blockers | Metoprolol, Atenolol | Reduced bronchodilating effect of salmeterol |
This information is not exhaustive. Consult your healthcare provider for personalized advice and to address any concerns about potential interactions before starting or continuing Advair Diskus.
