Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, before starting Sildenafil. This includes nitrates, which are used to treat chest pain (angina). Combining Sildenafil with nitrates can cause a dangerous drop in blood pressure.
Alpha-Blockers and Sildenafil
Alpha-blockers, often prescribed for high blood pressure or enlarged prostate, can interact with Sildenafil, potentially leading to dizziness or fainting. Your doctor may adjust your dosage or recommend alternative treatments.
Other Significant Interactions
Sildenafil can also interact with certain antifungals (like ketoconazole and itraconazole), HIV protease inhibitors (like ritonavir and indinavir), and macrolide antibiotics (like erythromycin and clarithromycin). These interactions can increase Sildenafil levels in your body, potentially causing side effects. Consult your doctor about safe medication combinations.
Grapefruit Juice and Sildenafil
Avoid grapefruit juice while taking Sildenafil. Grapefruit can increase Sildenafil’s concentration in your blood, potentially leading to unwanted side effects.
Summary of Potential Interactions
| Nitrates | Nitroglycerin, isosorbide mononitrate | Dangerous drop in blood pressure |
| Alpha-blockers | Terazosin, doxazosin | Dizziness, fainting |
| Antifungals | Ketoconazole, itraconazole | Increased Sildenafil levels |
| HIV Protease Inhibitors | Ritonavir, indinavir | Increased Sildenafil levels |
| Macrolide Antibiotics | Erythromycin, clarithromycin | Increased Sildenafil levels |
| Grapefruit Juice | Grapefruit juice | Increased Sildenafil levels |
Disclaimer:
This information is for general knowledge and does not replace professional medical advice. Always consult your doctor or pharmacist before making any changes to your medication regimen.
