Doxylamine succinate, while generally safe at recommended doses, can interact negatively with certain medications. Always inform your doctor or pharmacist of all medications, supplements, and herbal remedies you are taking before starting doxylamine.
Alcohol and CNS Depressants
Combining doxylamine with alcohol or other central nervous system (CNS) depressants, such as benzodiazepines (e. g., diazepam, alprazolam), opioids (e. g., codeine, morphine), or barbiturates, significantly increases the risk of drowsiness, slowed breathing, and impaired coordination. This combination can be dangerous and should be avoided.
MAO Inhibitors
Concurrent use of doxylamine with monoamine oxidase inhibitors (MAOIs) may result in an increased risk of serotonin syndrome, a potentially life-threatening condition characterized by symptoms such as confusion, agitation, muscle rigidity, and fever. Consult your doctor before combining these medications.
Other Medications
Doxylamine may also interact with certain antihistamines, antidepressants, and medications affecting the central nervous system. These interactions can enhance sedative effects, leading to increased drowsiness and dizziness. Your doctor can help you assess potential risks and recommend safer alternatives if necessary.
