Avoid combining oxycodone and gabapentin without strict medical supervision. This combination significantly increases the risk of serious side effects.
The primary risk stems from additive respiratory depression. Oxycodone slows breathing, and gabapentin can enhance this effect. This combination can lead to dangerously slow or shallow breathing, even respiratory arrest, particularly at higher doses or with pre-existing respiratory conditions.
Central nervous system (CNS) depression is another major concern. Both drugs depress the CNS, causing drowsiness, dizziness, confusion, and impaired coordination. The combined effect can be significantly stronger than the effect of either drug alone, resulting in a heightened risk of falls, accidents, and cognitive impairment. This risk increases with alcohol consumption.
Other potential side effects include:
| Increased Sedation | Excessive sleepiness, difficulty staying awake. |
| Nausea and Vomiting | More frequent and severe than with either drug alone. |
| Constipation | May become severe, requiring medical attention. |
| Cognitive Impairment | Difficulty concentrating, memory problems, impaired judgment. |
| Increased risk of overdose | Requires careful monitoring of dosage by a physician. |
If you are prescribed both oxycodone and gabapentin, inform all healthcare professionals about both medications. Closely monitor yourself for any unusual symptoms. Do not increase the dosage of either medication without consulting your doctor. Immediate medical attention is required if you experience severe drowsiness, difficulty breathing, or loss of consciousness.
Remember: This information is for educational purposes only and does not substitute professional medical advice. Always discuss any medication interactions with your doctor or pharmacist before mixing medications.
