Prednisone and prednisolone are both corticosteroids, but they differ in how your body processes them. Prednisone is a prodrug; your liver converts it into prednisolone, the active form. This means prednisolone directly affects your body’s cells, while prednisone needs this extra step.
Dosage differs because of this conversion. A doctor prescribes a higher dose of prednisone to compensate for the liver’s metabolic activity. Therefore, expect a higher prednisone dosage compared to prednisolone. Your individual metabolic rate also influences the needed amount.
Side effects are generally similar for both medications. However, because of the liver’s role in processing prednisone, individuals with liver problems might experience altered side effect profiles compared to those with healthy livers. Always inform your physician of pre-existing conditions.
Specific uses may slightly vary, although both treat inflammatory conditions and autoimmune disorders. Prednisolone is often preferred for certain conditions like asthma and inflammatory bowel disease, but both medications provide relief from similar symptoms. Your doctor’s expertise guides the final choice for your case.
The choice between prednisone and prednisolone depends on several factors, including your overall health, the specific condition being treated, and your individual response to medication. Consult your doctor or pharmacist to determine the most suitable option for your needs.
