Monitor your dog closely for these common side effects. Increased thirst and urination are frequent. Your dog may also experience increased appetite, leading to weight gain. Observe for changes in behavior; some dogs become more energetic, while others become lethargic or irritable.
Gastrointestinal upset is another possibility. Look for vomiting, diarrhea, or loss of appetite. Long-term prednisone use can weaken the immune system, increasing the risk of infections. Watch for any signs of illness like fever, lethargy, or persistent coughing.
Prednisone can also affect your dog’s appearance. You might notice thinning of the skin, hair loss, or increased skin fragility. In some cases, dogs develop cataracts or glaucoma. Regular eye exams are advised during prednisone treatment.
Less common, but serious, side effects include:
| Pancreatitis | Abdominal pain, vomiting, lethargy |
| Liver damage | Jaundice (yellowing of skin and whites of eyes), loss of appetite, vomiting |
| Muscle weakness | Difficulty walking, stumbling |
If you notice any of these signs, contact your veterinarian immediately. Early intervention is key to managing potential complications.


