Combining lisinopril and indomethacin increases the risk of hyperkalemia, a condition where potassium levels in your blood become dangerously high. This happens because indomethacin reduces the kidneys’ ability to excrete potassium, while lisinopril already has a tendency to raise potassium levels. Monitor your potassium levels closely if you’re taking both medications. Your doctor may order regular blood tests to check your potassium levels.
Monitoring Potassium Levels
Elevated potassium can cause irregular heartbeats, potentially leading to serious cardiac events. Symptoms of hyperkalemia include muscle weakness, nausea, and tingling. Report any of these symptoms to your doctor immediately. Your doctor might adjust your medication dosages or recommend alternative treatments to manage potassium levels.
Renal Function Considerations
This drug combination can also impair kidney function. Indomethacin decreases blood flow to the kidneys, which, combined with lisinopril’s effects, can further reduce kidney function, especially in patients with pre-existing kidney disease. Regular monitoring of kidney function through blood tests (creatinine and GFR) is necessary. Your physician may need to adjust your medications or monitor you more closely for signs of kidney damage. Hydration is crucial; adequate fluid intake can help support kidney function.
