Sildenafil citrate, the active ingredient in Sildenafil 50, works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5).
This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule in the process of penile erection. By blocking PDE5, sildenafil allows cGMP levels to rise.
- Increased cGMP relaxes the smooth muscles in the blood vessels of the penis. This relaxation increases blood flow into the penis. The increased blood flow facilitates an erection in response to sexual stimulation.
It’s important to understand that sildenafil doesn’t directly cause erections; it enhances the body’s natural response to sexual stimulation.
Sexual stimulation is necessary to trigger the release of nitric oxide. Nitric oxide activates the enzyme guanylate cyclase. Guanylate cyclase produces cGMP. Sildenafil’s inhibition of PDE5 prolongs the action of cGMP, leading to vasodilation and erection.
The duration of sildenafil’s effect varies, but generally, it lasts for several hours. Always follow your doctor’s instructions and dosage recommendations.
Remember to consult your physician before using sildenafil, especially if you have underlying health conditions or are taking other medications. They can assess your suitability for this medication and advise on potential drug interactions.
