Trazodone, while sometimes prescribed off-label for sleep disturbances in Alzheimer’s patients, carries potential side effects. Commonly reported are drowsiness, dizziness, and orthostatic hypotension (a sudden drop in blood pressure upon standing), potentially leading to falls, especially in older adults.
Cognitive impairment can worsen in some individuals. This includes increased confusion and disorientation. Monitor for changes in alertness and mental function.
Anticholinergic effects, such as dry mouth, constipation, and urinary retention, are possible. These are particularly concerning in Alzheimer’s patients already susceptible to such issues.
Cardiac effects, including prolonged QT interval (a measure of heart rhythm), are a potential risk factor, necessitating careful monitoring, especially for individuals with pre-existing heart conditions. Regular cardiac evaluations might be needed.
Serious side effects are rare but possible and include serotonin syndrome, a potentially life-threatening condition characterized by agitation, confusion, and fever. Immediate medical attention is required should these symptoms occur.
Always discuss trazodone use with a physician specializing in geriatric care and Alzheimer’s disease. Careful monitoring for side effects and regular check-ups are paramount to ensure patient safety and efficacy.
