Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, before starting Cialis. Certain combinations can lead to dangerous interactions.
Specifically, be aware of potential problems with:
- Nitrates: Combining Cialis with nitrates (found in medications for chest pain) can cause a dangerous drop in blood pressure. This combination is strictly contraindicated. Alpha-blockers: These drugs, often prescribed for high blood pressure or enlarged prostate, can increase the risk of low blood pressure when taken with Cialis. Your doctor may need to adjust your dosages. Other ED medications: Taking Cialis with other phosphodiesterase-5 (PDE5) inhibitors like Viagra or Levitra is unsafe and can lead to serious side effects. CYP3A4 inhibitors: These medications, including some antifungals and HIV protease inhibitors, can increase Cialis levels in your blood, potentially intensifying side effects. Your doctor may recommend a lower Cialis dose. CYP3A4 inducers: These drugs, such as rifampin and St. John’s Wort, can decrease Cialis effectiveness. Dosage adjustments may be needed.
This list isn’t exhaustive, and many other medications can interact with Cialis. Your healthcare provider can provide a more personalized assessment of potential drug interactions based on your specific medical history and current medications.
Discuss all your medications: Open communication with your doctor is key to safe medication use. Never self-medicate: Always consult your doctor before starting or stopping any medication, including Cialis. Report any unusual side effects: Contact your doctor immediately if you experience unexpected or concerning symptoms while taking Cialis.


