Clomid, or clomiphene citrate, stimulates the pituitary gland to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Increased FSH promotes follicle development in the ovaries, leading to the maturation of multiple eggs instead of just one. This increased egg production significantly raises the chance of a multiple pregnancy, including twins.
The exact risk of twins with Clomid varies. Studies show a twin pregnancy rate between 5% and 10%, significantly higher than the 1-3% natural twinning rate. This elevated risk is directly related to the dose of Clomid and the individual’s response to the medication. Higher doses generally lead to a greater chance of multiple pregnancies.
Factors beyond Clomid dosage influence the likelihood of twins. Age plays a role, with younger women tending to have a higher response to Clomid. Underlying ovarian reserve also impacts follicle development. Women with higher ovarian reserve may produce more eggs, increasing twin possibilities.
Your fertility specialist will carefully monitor your response to Clomid via ultrasound scans. This allows for personalized dosage adjustments, minimizing the risk of higher-order multiples (triplets or more) while maximizing your chances of a healthy pregnancy.
Open communication with your doctor is paramount. Discuss your concerns about multiple pregnancies and your personal risk factors. Together, you can weigh the benefits of Clomid against the potential for twins and make informed decisions about your treatment.


